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Antidepressants Bupropion and Mirtazapine

Antidepressants:Bupropion and Mirtazapine

Antidepressants refer to a diverse group of drugs that are united bytheir ability alleviate or eliminate depression. In spite of theirclassical differences, the mechanisms of the action of these drugs issimilar. Antidepressants have been used for a considerably longperiod in medical history. In spite the long historic use, theiroverall clinical effectiveness for the long term remains unclear.Bupropion and mirtazapine are examples of antidepressant drugs. Thispaper provides a summary of the readings on these drugs, comparesthem with others, and provides a reflection on the significance ofthe knowledge gained.

Like other antidepressants, bupropion is used to treat (alleviate oreliminate) depression. Also, it is used to addictive smoking andseasonal affective disorder. Prescribers and users should avoidconsidering it if a MAO inhibitor had been used less than daysearlier. It may cause seizures. Other side effects include loss ofinterest in sex, vision changes and muscle pain amongst others (Patelet al., 2016). Mirtazapine, on the other hand, is anantidepressant that is used to treat major depressive disorders. Likebupropion, it should not be used if a MAO inhibitor has been usedbefore. Its main side effects include racing thoughts, dizziness,constipation, weight gain and vision changes.

Both bupropion and mirtazapine have a relatively narrow therapeuticindex. This implies that the probability of the drugs causing aseizure is considerably low especially for doses below 400 mg perday. Both drugs have 30% likelihood to induce seizure. Even so, theydiffer in various pharmacodynamics properties. One such property isthe dose response where bupropion has a significant one whilemirtazapine has a narrow one. Bupropion’s lag time is highlydependent on the purpose for which it is used. As an antidepressant,it has a lag time of 21 days to one month. While this is so,mirtazapine has a lag time of five to seven weeks. It is, therefore,evident that when both are used as antidepressants, mirtazapine has alonger lag time than bupropion (Drugs.com, 2016). A small section ofthe population that uses bupropion builds tolerance on it when theyuse it over a long period. Also, bupropion reduces alcohol toleranceto its users in the use period. For mirtazapine, tolerance is mainlydeveloped after 2 to 6 weeks of the drug’s use. Besides, the drug’stolerance is built immediately after ingestion. The common physicaleffects of bupropion include itching, skin rash, urinary frequencygeneral body weakness, and abdominal pains. While this is so, thephysical effects of mirtazapine include blurred vision, ill feeling,rash, light-headedness and weight gain.

Information regarding the pharmacodynamics of both bupropion andmirtazapine is important in as far as helping persons who abuse thesedrugs is concerned. The abusers could do it either knowingly orunknowingly. Those who abuse them unknowingly mainly do so due tolack of adequate and accurate information. As such, my understandingfor the functioning of these drugs enables me to share my knowledgewith the abusers. The knowledge gained on both the physical andnon-physical effects of drugs is important in as far as understandinga person’s drug abuse experience is concerned (Lapidus et al.,2013). Besides, a person’s real and purported drug tolerance wouldhelp me to better understand their drug abuse experience. This isbecause, the longer the period one abuses a specific drug, the highertheir tolerance on that particular drug.

To wrap things up, bupropion and mirtazapine are two commonly usedantidepressants with similarities and differences as well. Beyondbeing used as antidepressants, the two drugs have additional usessuch as reducing addiction. As evident in this paper, the benefits ofthe two, when put under proper use, cannot be underestimated. Evenso, they have various side effects, and their impact is dependent onthe nature of the bodies of the specific individuals who use them.Knowledge relating to these drugs is, however, important in helpingtheir abusers and understanding their experience in abusing them.


Bupropion Side Effects in Detail – Drugs.com. (2016).Drugs.com. Retrieved 13 November 2016, fromhttps://www.drugs.com/sfx/bupropion-side-effects.html

Lapidus, K., Soleimani, L., &amp Iosifescu, D. V. (2013).Depression: Diagnosis and Treatment. In Essentials of HospitalMedicine: A Practical Guide for Clinicians (pp. 949-961).

Mirtazapine Uses, Dosage &amp Side Effects – Drugs.com.(2016). Drugs.com. Retrieved 13 November 2016, fromhttps://www.drugs.com/mirtazapine.html

Patel, K., Allen, S., Haque, M. N., Angelescu, I., Baumeister, D., &ampTracy, D. K. (2016). Bupropion: a systematic review and meta-analysisof effectiveness as an antidepressant. Therapeutic advances inpsychopharmacology, 2045125316629071.