- May 9, 2020
Bone regeneration with mesenchymal stem cells
Boneregeneration with mesenchymal stem cells
Developmentsin molecular biology and biotechnology have revolutionized medicine.One of the recent discoveries in therapeutics has been the use ofmesenchymal stem cells (MSCs) in bone regeneration. These cells arecapable of differentiating to form different organs in the body.According to the article “Boneregeneration with mesenchymal stem cells," theauthors state that MSCs have revolutionized modern treatments of bonediseases and conditions. The article states that bones have theintrinsic capacity to regenerate. Some complex clinical conditionsmay interfere with these processes. Examples of such conditionsinclude trauma, tumors connective tissue malfunctions andhypophosphatasia. The tissue engineering approach which makes use ofMSCs is the best intervention to managing such conditions. Thearticle affirms that current therapies used in treating boneconditions have often failed and are very expensive. It also suggeststhat MSCs can also be used alongside growth factors and platelet-richplasma. If effectively used, this can help improve the healingproperties of MSCs. Other combinations that have indicatedpossibility of good clinical outcomes include the use of MSC withbiomaterials especially when bones need structural support to heal.The article, however, calls for more research into the use of MSCs.The authors believe that with more research, it will be possible touncover other potential uses of MSCs in health care and medicine as awhole. This will, in turn, result in more effective and cheaptreatment options for bone diseases.
Insupporting its stand, the authors have included cases where MSCstherapy has been effective. For example, the article states that inone study, patients who were put under MSCs therapy did not developany complications after treatment. Additionally, mesenchymal stemcells were effectively used to treat four patients with segmentaldiaphyseal defects in the tibia. Similarly, MSCs have been used totreat ulna and humerus fractures. In all these patients, there was agood integration of the implants with other tissues. The articlealso describes a pilot study that was conducted in 5 childrensuffering from osteogenesis imperfect. In this case, the interventionwas very successful and cost-effective compared to other options. The authors also discuss what culturing of mesenchymal stem cellsentail. Here, they state that a combination of hyaluronic acid,calcium chloride, platelet-rich plasma (PRP) and injected autologousadipose-tissue-derived stem cells can regenerate bones inosteonecrosis. It is evident that with this technique, it will bepossible to obtain more mesenchymal stem cells. Some of the sourcesof mesenchymal stem cells include articularcartilage, periosteum, synovial membrane, andumbilicalcordon blood and trabecular bone. The article does expound on theprocedures used to obtain mesenchymalstem cells from umbilicalcordon blood and other cells. For example, there have been a lot ofcontroversies regarding the procedures used. Some section of thepopulation has often termed it unethical. They state that use ofumbilicalcordon blood undermines the quality of life.
Kon,E., Filardo, G., Rotti, A., Di Martino, A., Hamdan, M., De Pasqual,L. & Marcacci, M. (2012). Bone regeneration with mesenchymal stemcells. Clinicalcases in mineral and bone metabolism, 9(1),24-27.