- May 4, 2020
Alcohol dependence is a major problem in the society. Alcoholism isthe main cause of most of today’s health, mental, and behavioraldisorders drugs to curb the addiction are in high demand consideringthe massive usage of alcohol today. The medicines include Naltrexone,Acamprosate, and Disulfiram. Acamprosate is one of the major genericdrugs and is used for a period of 12 months to maintain alcoholabstinence after a patient ceases drinking. The danger ofnon-compliance of the dosage due to the alcohol behavior of thepatients makes it ideal to formulate a one-time administration of aremedy that will release the drug for a longer period. For anextended-release delivery of Acamprosate, polymer microspheres-(PLGA)50/50, which are entirely biocompatible, as well as biodegradable,were formulated. As noted, they release a constant rate of 130 mg inone day. A single core and shell microspheres with a radius of 40 µmis recommended to match the specifications required. The high usageof alcohol around the globe has increased the demand for drugs tocure related disorders and dependencies. Also, the drugs used to curbthis problem are limited, taking into consideration that somemedicines that were used are now going out of the market, forexample, Disalfiram, and now Naltrexone, as well as Acamprosate arebecoming the major medications used all over the world. Besides, theAcamprosate drug in the new controlled-release-formulation will savethousands of dollars, which could have been utilized in the otherremedies and the daily dosage of the medicine. At the same time, itreduces the risk of wasting due to the prone non-compliance-tendencyof alcohol users. The implementation of the advanced procedure willhave an active role in the curing of alcoholism related problems,which are experienced in the society today.