- April 20, 2020
ORGANO VANADIUM 6
Organo-vanadiumrefers to the chemistry of organometalliccompound which is made up of a chemical bond between carbon vanadium.These compounds are believed to exercise more effectiveness than theinorganic vanadium compounds (Clark,Brown, Bailar, Emeléus, & Nyholm, 2013).The complexof organo-vanadium is foundto be a potent activator of the protein kinase B, signaling pathwayand protein tyrosine phosphorylation, a mechanism used forinsulinomimesis (Fedorova,Buryakina, Vorobieva, & Baranova, 2013).Because of this, the organo-vanadium remains poorly defined.Importantly, it should benotedthat the organo-vanadium is a nutraceutical method employedin the treatment of diabetes.
Althoughthe chemical structure of organo-vanadium constitutes of a compoundbetween carbon and vanadium, some of the most common elements used asthe anti-diabeticproperty is the bis (maltoalto)oxy vanadium. The bis (maltoalto)oxy vanadium is mainly used to boost and ensure the effectivereduction of glucose levels in diabetic patients (Mehdi,& Srivastava, 2005).When exposed to the environment, organovanadiumcompounds present no effect. As a result, the OVCs are consideredsafer due to its inability to cause gastrointestinal irritation andtoxicity of hepatic. The type two diabetic patients areseenas the most vulnerable population towards the OVCs therapy. That ismainly due to the increased sense of respiratory effects caused bythe organovanadiumcompounds. The main reason for this particular study is to provide aclear and detailed overview of the chemical properties involved inthe organovanadiumcompound and its impact on the general well-beingof patients.
Organo-vanadiumcompounds can exist both naturally or through an anthropogenicsource such as drugs. The increased sense toxic exposure isnoticeable in individuals with acute levels of vanadium. According tothe United States Department of Health and Human Services PublicHealth Service Agency for Toxic Substances and Disease Registry(2012), an individual become exposed to organovanadiumthrough inhalation or oral ingestion. Itfosters the growth and development of tissue dysfunction andhypertension as well as a general reduction in lung capacity. Theeffects of these sources arefeltafter their release into water, land, atmosphere and the environmentas a whole.
Informationon health effects
Meanwhile,it is good to note thattheorgano-vanadium compounds fosterthe growth and development of cell differentiation and proliferation.Itis mainly due to their ability toimprove insulin resistance in diabetes mellitus model. Through this,the insulin becomes highly sensitive in both the muscle and liver oftypeII diabetic patient. Consequently, since the organo-vanadiumcompounds affect insulin-likesystems that arelocatedin the Vitroand Vivo,it fosters the improvement of glucose homeostasis in the body.Because of this, the body candevelop astableoxidization balance.
InformationSummary of the Paper reviewed by my peer group
Titleof the paper: Biochemistry(Moscow) Supplement Series B
Authors:Fedorova,E. V., Buryakina, A. V., Vorobieva, N. M., & Baranova, N. I.
Citation:(Fedorova,Buryakina, Vorobieva, & Baranova, 2013).
Organo-vanadiumcompounds are released anthropogenic sources. Drugs are also a sourceof this compound,and the most susceptible groups are people with type II of diabetes.Although the mechanisms of toxicity of the organo-vanadium compoundsremain unknown, they are used to ensure the efficientstimulation of someenzymes such as NADPH oxidase and adenylate cyclase as well astyrosine kinase phosphorylase (Mozaffari,2013).Thestudy on this paper aims at analyzing the source of this compound andthe effects on the health environment.
Theobjectiveswere toprovide a clear and detailed overview of the chemical propertiesinvolved in the organovanadiumcompound and its impact on the general well-beingof patients, to determinethe sources of Organo-Vanadium and to come up with health effectsrelated to Organo-vanadium.
Themethods used includeanalysis of the bonding structure of the compound, analyzingits physicaland chemical properties and listing them down. The paper alsoassessed the rate of its exposure toorgano-vanadium compounds and the graphical method used inrepresentingit.
Organo-vanadiumchemical structure constitutes a bond between carbon and Vanadiumchemically combined. Its chemical structures undergo a chemicalprocess called thermaldecompositions.Other chemical properties include the presenceof insulin-likeand mimic featuresofits structure.
Thecompound poses asignificantenvironmental health risk as it causes respiratory effects. Giventhat the mechanism of toxicity of the organo-vanadium compounds canfoster the growth and development of tissue dysfunction andhypertension as well as a general reduction in lung capacity, itcreates an array effects to the environment. That is mainly due tothe air irritation it emits into the environment after itsintermediate oral exposure.
Fedorova,E. V., Buryakina, A. V., Vorobieva, N. M., & Baranova, N. I.(2013). Thevanadium compoundschemistry, synthesis, insulinmimeticproperties. Biochemistry (Moscow) Supplement Series B: BiomedicalChemistry, 7(4), 259-270.
Mehdi,M. Z., & Srivastava, A. K. (2005). Organo-vanadiumcompounds are potent activators of the protein kinase B signalingpathway and protein tyrosine phosphorylation: mechanism ofinsulinogenesis.Archivesof biochemistry and biophysics,440(2),158-164.
USDepartment of Health and Human Services Public Health Service Agencyfor Toxic Substances and Disease Registry. (2012). ToxicologicalProfile for Vanadium.
Clark,R. J. H., Brown, D., Bailar, J. C., Emeléus, H. J., & Nyholm,R. (2013). The Chemistry of Vanadium, Niobium, and Tantalum: PergamonTexts in Inorganic Chemistry.
Mozaffari,M. S. (2013). New Strategiesto Advance Pre/Diabetes care: Integrative approach by PPPM.Dordrecht: Springer